In the Mediterranean region, two thirds of the population live in urban areas. By 2050, the United Nations Human Settlements Programme predicts that the urban population will grow to around 170 million in the countries on the northern shore and to over 300 million to the south and east. This fact generates serious challenges: growing number of slums, inadequate infrastructures and services (waste collection, potable water, mobility, health threats). Cities play a major role in tackling these challenges. That is why a new sustainable approach to spatial planning and management in Mediterranean cities, offering longer-term sustainable solution, is needed. Combining the capitalisation of the Interreg MED project “CESBA MED: Sustainable Cities” with the ENI CBC MED project “GreenBuilding”, Sustainable MED Cities will provide Mediterranean municipalities with a system of innovative tools and methodologies to develop effective policies, strategies and action plans in relation to the Mediterranean Strategy for Sustainable Development 2016-2025. The project will also deliver innovative capacity-building programmes for Mediterranean cities to step up their capacity to drive the urban regeneration.